High Fat Diet Without Weight Gain: We all know that high fat diet will increase the weight. But, a new study revealed that maintaining a high fat can also control your weight. The researchers in this study revealed how activating a specific protein pathway can prevent the growth of fat cells in mice in response to a high-fat diet. They suggest that there will be a day where you can eat whatever you can but won’t gain weight.
The investigators are confident about this and also tell that it will be treatment for obesity. Senior study investigator Fanxin Long, Ph.D. — who works in the Washington University School of Medicine in St. Louis, MO — and colleagues say that their findings could bring us closer to a new treatment strategy for obesity, which is, at present, thought to affect more than a third of adults in the United States.
High Fat Diet Without Weight Gain is Possible in Future:
Foods high in fat, particularly saturated fats, are thought to be a main driver of obesity, especially when consumed in large amounts. But Long and colleagues suggest that there could be a way to prevent weight gain induced by a high-fat diet. The authors quoted in their paper, Here by inducing expression of constitutively active Smoothened (SmoM2) or Gli2 (ΔNGli2) in the adipocyte lineage of postnatal mice, we show that targeted activation of Hh signaling suppresses high-fat-diet-induced obesity and improves whole-body glucose tolerance and insulin sensitivity.
“More importantly,” notes Long, “when we did metabolic studies, we found that the animals with the active Hedgehog pathway not only were leaner, they also had lower blood glucose levels and were more sensitive to insulin. Fat gain is due mainly to increased fat cell size,” explains Long. “Each fat cell grows bigger so that it can hold larger fat droplets. We gain weight mainly because fat cells get bigger, as opposed to having more fat cells.”
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